Founded: 1967
 Location: 120 McArthur Highway, Marulas, Valenzuela City, Philippines

It is all started when Jose C.Olivares, a chemistry professor by vocation but with strong entrepreneurial spirit, and his son-in-law,Dr.Vicente M.Santos, an obstetrician, founded the Our Lady of Fatima Hospital in 1967. It soon became the primary provider of medical services to the residents of Valenzuela and its neighbouring towns. With a vision of creating medical complex that will be a training center for competent health care providers, Mr.Olivares created the Fatima Medical Science Foundation Inc, and initially established the Our Lady of Fatima College of Nursing in 1973.

With the status of University, OLFU in 2003, Offered Bachelor of Secondary Education and Bachelor of Elementary Education.It has since then produced teachers that mentor students in private and public schools throughout the country.

In 2007, in anser to the growing demand to establish more OLFU campuses, the administration purchased and developed a 4-hectare area this is now OLFU-Anti-polo. The sprawling campus provides the same course offerings as in its sister campuses.

In 2009, the commission on Higher Education awarded the University. Autonomous status for its accomplishments, adherence to quality assurance, and commitment to public responsibility and accountability as a higher education institution. As an autonomous higher educational institution. OLFU has attained what several educational institutions strive for but few attain.